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Peptide record

TPDB62288

DPV6 Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB62288
DPV6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Cys addition
Sequence
GRPRESGKKRKRKRLKP
Physicochemical Analysis
C88H165N37O21
ANDCQHIMFTWYV
RK
2077.51
12.59
10
1
1
+9
11.51
-2.735
22.94
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
1
L
5
K
0
M
0
F
2
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 5 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C88H165N37O21
2077.51
12.59
+9
11.51
-2.735
Free
L
Linear
Cys addition
NCC(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (PO and IgG)
Cytoplasm
Energy-dependent endocytic process involving cell membrane lipid rafts
In vitro
CCEETTEESSGGGCCCC
Additional Detail Fields 1 fields
CCEETTEESSGGGCCCC