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Peptide record

TPDB62283

TAT-anti-gyrA PNA/scPNA Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62283
TAT-anti-gyrA PNA/scPNA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GRKKRRQRRRYK
Physicochemical Analysis
C70H130N34O15
ANDCEHILMFPSTWV
R
1688.02
12.71
9
0
1
+9
7.48
-3.658
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
88.27
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C70H130N34O15
1688.02
12.71
+9
7.48
-3.658
Free
L
Cationic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
TAT-anti-gyrA PNA showed an antimicrobial effect against S. pyogenes M49 strain 591 and M1 strain AP1 with the lowest MIC at 15.6 mM. Larvae treated with TAT-anti-gyrA PNA showed increased survival compared with the control.
In vitro and in vivo