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Peptide record

TPDB62282

TAT-heart8P Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62282
TAT-heart8P
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-GRKKRRQRRRPQWVELHFFN-NH2
Physicochemical Analysis
C120H192N46O26
ADCIMSTY
R
2695.14
12.71
9
1
5
+7
7.26
-2.065
34.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
204.07
3
Residue Composition
number
0
A
6
R
1
N
0
D
0
C
1
E
2
Q
1
G
1
H
0
I
1
L
2
K
0
M
2
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 1 H: 1 I: 0 L: 1 K: 2 M: 0 F: 2 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
20
C120H192N46O26
2695.14
12.71
+7
7.26
-2.065
Amidation
L
Cationic
Linear
Acetylation
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mouse And Human Cardiomyocytes Mouse Cardiac Tissues

Assay & Model

12-week-old male C57BL/6J mice
12-week-old male C57BL/6J mice

Source & Reference

CPPsite3.0
CPPsite3
patent application (US63/276,028) and international publication (WO2020/229362A1)

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
Fluorophore Cys(Cy5.5.) or NODAGA-Chelator
Rapid intracellular internalization of TAT-heart8P-Cys(5.5)
In-vitro, in-vivo and ex vivo
CCSSSSCCCCSSCSSCCCC
Additional Detail Fields 1 fields
CCSSSSCCCCSSCSSCCCC