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Peptide record

TPDB62278

Tat-PKI Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB62278
Tat-PKI
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
GRKKRRQRRRPPQTYADFIASGRTGRRNAI
Physicochemical Analysis
C150H258N62O40
CEHLMWV
R
3570.09
12.70
11
1
7
+10
10.22
-1.767
36.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
41.74
7
Residue Composition
number
3
A
9
R
1
N
1
D
0
C
0
E
2
Q
3
G
0
H
2
I
0
L
2
K
0
M
1
F
2
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 9 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 2 L: 0 K: 2 M: 0 F: 1 P: 2 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
30
C150H258N62O40
3570.09
12.70
+10
10.22
-1.767
Free
L
Linear
Conjugation with rhodamine B
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO K1, HeLa, A549 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (rhodamine)
Less than polyarginine-PKI, Antp-PKI and Transport
Lipid raft-dependent but clathrin-independent endocytic process
In vitro
CCCCSCCCSCCSCCTTTTTTTSCCCCCCCC
Additional Detail Fields 1 fields
CCCCSCCCSCCSCCTTTTTTTSCCCCCCCC