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Peptide record

TPDB62277

TAT Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62277
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
GRKKRRQRRRPPQRKC
Physicochemical Analysis
C85H160N42O19S1
ANDEHILMFSTWYV
R
2106.54
12.80
10
0
0
+10
10.47
-3.206
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
7
R
0
N
0
D
1
C
0
E
2
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C85H160N42O19S1
2106.54
12.80
+10
10.47
-3.206
Free
L
Cationic
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

KB and HT-29 cells

Assay & Model

Male Sprague Dawley rats
Male Sprague Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Protein (Calcetonin)
In vitro and in vivo
CCCCCCCCCCCSSCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

KB (human mouth epidermal carcinoma) and HT-29 (colon adenocarcinoma)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Protein [synthetic salmon CT (sCT)]
In vitro
CCCCCCCCCCCSSCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCSSCCC