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Peptide record

TPDB62266

TAT Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62266
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: FITC-labeled
Sequence
GRKKRRQRRRPPGC
Physicochemical Analysis
C70H131N35O16S1
ANDEHILMFSTWYV
R
1751.10
12.71
8
0
0
+8
8.10
-2.843
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C70H131N35O16S1
1751.10
12.71
+8
8.10
-2.843
Addition of Cysteine
FITC-labeled
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2.2.15, Hepg2, And L-02 Cells

Assay & Model

6- to 7-week-old BALB/c mice.
6- to 7-week-old BALB/c mice.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Peptide nucleic acid (PNA-DR)
Cytoplasm and Nuclei
The signals indicated the successful synthesis of Tat-PNA-DR.
In vitro and in vivo
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC