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Peptide record

TPDB62252

Tat-G Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB62252
Tat-G
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Addition of Glycine Chemical: Micelles
Sequence
GRKKRRQRRRG
Physicochemical Analysis
C57H112N32O13
ANDCEHILMFPSTWYV
R
1453.72
13.10
8
0
0
+8
7.44
-3.555
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C57H112N32O13
1453.72
13.10
+8
7.44
-3.555
Addition of Glycine
Micelles
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rn33B Cell Lines

Assay & Model

Ten-week-old Sprague–Dawley (SD) male rats
Ten-week-old Sprague–Dawley (SD) male rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FAM-siRNA targeting TNF-α (siTNF-α)
The intracellular siRNA uptake of siRNA/MPEG-PCL-Tat complexes at an N/P ratio of 30 was seen to have the greatest intracellular uptake efficacy.
Macropinocytosis
In vitro and in vivo
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC