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Peptide record

TPDB62244

TAT (Dex-1) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62244
TAT (Dex-1)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Alexa 488 labelling N-terminal: Amidation
Sequence
GRKKRRQRRPPQ
Physicochemical Analysis
C64H119N31O15
ANDCEHILMFSTWYV
R
1562.85
13.01
7
0
0
+7
8.10
-3.408
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C64H119N31O15
1562.85
13.01
+7
8.10
-3.408
Free
Alexa 488 labelling
L
Cationic
Linear
Amidation
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

ARPE-19 Cells

Assay & Model

Pigmented 2.5–3.0 kg female Dutch belted rabbits
Pigmented 2.5–3.0 kg female Dutch belted rabbits

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Dexamethasone via cleavable peptide-based linker (PCL)
Conjugates were internalized within the ARPE-19 cells without association at the cell surface
In vitro and in vivo
CCCCC
Additional Detail Fields 1 fields
CCCCC