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Peptide record

TPDB62225

SFTI-M5 Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62225
SFTI-M5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
N-terminal: Conjugation with Alexa Flour 488
Sequence
GRCTRSIPPKCWPD
Physicochemical Analysis
C69H110N22O19S2
ANEQHLMFYV
P
1615.89
9.15
3
1
2
+2
2.83
-1.036
27.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
348.11
4
Residue Composition
number
0
A
2
R
0
N
1
D
2
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
0
F
3
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C69H110N22O19S2
1615.89
9.15
+2
2.83
-1.036
Free
L
Cationic
Cyclic
Conjugation with Alexa Flour 488
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Fluorophore (Alexa Fluor 488)
Equal to SFTI-1
Non-receptor and non-specific endocytosis dependent mechanism
In vitro
CCCCCCCCCTTSCC
Additional Detail Fields 1 fields
CCCCCCCCCTTSCC