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Peptide record

TPDB62223

SFTI-M4 Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62223
SFTI-M4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugation with Alexa Flour 488
Sequence
GRCTKSIPPICWPK
Physicochemical Analysis
C71H116N20O17S2
ANDEQHLMFYV
P
1585.95
9.92
3
0
3
+3
1.47
-0.421
55.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
354.68
4
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
2
I
0
L
2
K
0
M
0
F
3
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 2 M: 0 F: 0 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C71H116N20O17S2
1585.95
9.92
+3
1.47
-0.421
Free
L
Cationic
Cyclic
Conjugation with Alexa Flour 488
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Fluorophore (Alexa Fluor 488)
Equal to SFTI-1
Non-receptor and non-specific endocytosis dependent mechanism
In vitro
CCCCCCCCSSSSCC
Additional Detail Fields 1 fields
CCCCCCCCSSSSCC