Back to search

Peptide record

TPDB62221

SFTI Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62221
SFTI
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
GRCTKSIPPICFPD
Physicochemical Analysis
C67H108N18O19S2
ANEQHLMWYV
P
1533.82
8.29
2
1
3
+1
2.43
-0.129
55.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
8.15
4
Residue Composition
number
0
A
1
R
0
N
1
D
2
C
0
E
0
Q
1
G
0
H
2
I
0
L
1
K
0
M
1
F
3
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 1 M: 0 F: 1 P: 3 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C67H108N18O19S2
1533.82
8.29
+1
2.43
-0.129
Free
L
Amphiphilic
Cyclic
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cd34+ Endothelial Cells , HNSCS, Neurons And Astrocytes

Assay & Model

Male Sprague Dawley rats weighing 250–300 g
Male Sprague Dawley rats weighing 250–300 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Amphiphilic
Protein derived
unbound SFTI-1 across the BBB having Kp,uu,brain, of 13% in rat model.
Endocytosis
In vitro and in vivo
CCCCCCCCSSCCCC
Additional Detail Fields 1 fields
CCCCCCCCSSCCCC