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Peptide record

TPDB62213

p1932 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62213
p1932
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
GPPPQGGNKPQGPPPPGKPQ
Physicochemical Analysis
C86H134N26O25
ARDCEHILMFSTWYV
P
1932.17
10.60
2
0
0
+2
8.24
-1.910
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
3
Q
5
G
0
H
0
I
0
L
2
K
0
M
0
F
9
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 3 G: 5 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 9 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C86H134N26O25
1932.17
10.60
+2
8.24
-1.910
Free
L
Amphipathic
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Gingival Fibroblast (Hgfs) And Squamous Cancer Cell Line (Pe/Ca-Pj15 Cells )

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Cytoplasmic Organelles And Nuclei
The continuous increase of fluorescence of p1932 peptide was faster in the PJ15 cell line than in hGFs, at least within the first 15 min, but the amount of peptide internalized after 30 min was comparable in both cell types.
Caveolae-mediated and lipid raft-mediated endocytosis
In vitro
CTTCCCCCCCCC
Additional Detail Fields 1 fields
CTTCCCCCCCCC