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Peptide record

TPDB62202

α2H Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62202
α2H
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
GNGEQREMAVSRLRDCLDRQA
Physicochemical Analysis
C94H162N36O34S2
HIKFPTWY
R
2404.66
6.51
4
4
6
-0
9.61
-1.157
60.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
2
A
4
R
1
N
2
D
1
C
2
E
2
Q
2
G
0
H
0
I
2
L
0
K
1
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 2 C: 1 E: 2 Q: 2 G: 2 H: 0 I: 0 L: 2 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C94H162N36O34S2
2404.66
6.51
-0
9.61
-1.157
Free
L
Amphipathic and hydrophobic
Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Hbmec E. Coli K1, Salmonella, And Shigella

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic and hydrophobic
Protein derived
FITC dye and Gentamicin
Cytoplasm
α2H-FITC showed less efficient uptake for α1H-FITC
Lipid raft-mediated endocytosis and direct translocation
In vitro
CCCGGGGGTTGGGGCCCC
Additional Detail Fields 1 fields
CCCGGGGGTTGGGGCCCC