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Peptide record

TPDB62201

AA-Sema-OH Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB62201
AA-Sema-OH
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Biotinylation
Sequence
GNAAGRNRR
Physicochemical Analysis
C36H66N20O12
DCEQHILKMFPSTWYV
R
971.05
12.70
3
0
2
+3
2.95
-1.967
22.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
3
R
2
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C36H66N20O12
971.05
12.70
+3
2.95
-1.967
Free
L
Linear
Biotinylation
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO pgs745

Assay & Model

Athymic nu/nu female mice
Athymic nu/nu female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
silver-based nanoparticles (AgNPs) labelled with CF555 fluorescent dye
Endosomal compartments
AgNP-Sema-OH and, to a lesser extent, AgNP-AA-Sema-OH entered the NRP1-transfected CHO pgs745 cells
HS-dependent pathway with the C-end rule (CendR) mechanism
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC