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Peptide record

TPDB62185

CADY-1 Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62185
CADY-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLWWKAWWKAWWKSLWWRKRKRKA
Physicochemical Analysis
C168H235N47O26
NDCEQHIMFPTYV
W
3329.01
12.72
9
0
13
+9
-7.92
-1.346
45.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
44000
1321.71
1
Residue Composition
number
3
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
6
K
0
M
0
F
0
P
1
S
0
T
8
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 8 Y: 0 V: 0
Chemical Descriptors
24
C168H235N47O26
3329.01
12.72
+9
-7.92
-1.346
L
Amphipathic
Linear
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

The HeLa cells

Assay & Model

Human tumour xenograft female DBA/2 mice
Human tumour xenograft female DBA/2 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Small molecule drug (Doxorubicin)
Compared to free doxorubicin, the CADY-1/doxorubicin complex exhibited remarkable cell death activity
In vitro and in vivo
CCSHHHHTTTHHHHHHHHHTTCCC
Additional Detail Fields 1 fields
CCSHHHHTTTHHHHHHHHHTTCCC