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Peptide record

TPDB62184

GL1 Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62184
GL1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-GLWRAWLWKAFLASNWRRLLRLLR-NH2
Physicochemical Analysis
C149H229N45O27
DCEQHIMPTYV
L
3082.74
13.00
6
0
15
+6
-7.36
0.004
126.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
713.65
2
Residue Composition
number
3
A
5
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
7
L
1
K
0
M
1
F
0
P
1
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 7 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
24
C149H229N45O27
3082.74
13.00
+6
-7.36
0.004
Amidation
L
Cationic
Linear
Acetylation
NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cy3-labeled GAPDH siRNA
Cytosol In Perinuclear
Achieved 95% uptake of siRNA higher than Lipofectamine 2000 (Lipo 87%)
In vitro
CCCCTTTCTTSCC
Additional Detail Fields 1 fields
CCCCTTTCTTSCC