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Peptide record

TPDB62182

PSR Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62182
PSR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticle
Sequence
GLWRALWRLLRSLWRLWRKA
Physicochemical Analysis
C127H198N40O22
NDCEQHIMFPTYV
L
2637.22
13.00
6
0
12
+6
-5.92
-0.240
127.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
834.21
1
Residue Composition
number
2
A
5
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
1
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
20
C127H198N40O22
2637.22
13.00
+6
-5.92
-0.240
Free
Nanoparticle
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Neuro 2A-Luc+ (Firefly Luciferase) Murine Neuroblastoma And B16-F10-Luc+ Murine Melanoma Cell Lines.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
siRNA
PSR:siRNA seemed to be better candidates as CADY:siRNA revealed a gene silencing of > 70% in Neuro-2a-Luc+ and of > 40% in B16-F10-Luc+ cells.
In vitro
CTHHHHHHHHHHHHHHHCCC
Additional Detail Fields 1 fields
CTHHHHHHHHHHHHHHHCCC