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Peptide record

TPDB62176

PG16 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62176
PG16
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticle
Sequence
GLWRALWRGLRSLWRLLWKV
Physicochemical Analysis
C125H193N37O22
NDCEQHIMFPTY
L
2566.14
12.88
5
0
12
+5
-6.48
0.085
136.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
857.32
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
6
L
1
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 6 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 1
Chemical Descriptors
20
C125H193N37O22
2566.14
12.88
+5
-6.48
0.085
Free
Nanoparticle
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Neuro 2A-Luc+ (Firefly Luciferase) Murine Neuroblastoma And B16-F10-Luc+ Murine Melanoma Cell Lines.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
siRNA
PG16:siRNA revealed a poor luciferase knock-down effect with a minimum of 60% for Neuro-2a-Luc+ and 50% for B16-F10-Luc+ cells.
In vitro
CTHHHHHHHHHHHHHHHHTTC
Additional Detail Fields 1 fields
CTHHHHHHHHHHHHHHHHTTC