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Peptide record

TPDB62163

CaaX-1 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62163
CaaX-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GLRKRLRKFRNKSKTKCVIM
Physicochemical Analysis
C107H196N38O24S2
ADEQHPWY
K
2463.09
12.43
9
0
6
+9
5.93
-0.970
73.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
4
R
1
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
2
L
5
K
1
M
1
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 5 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C107H196N38O24S2
2463.09
12.43
+9
5.93
-0.970
Free
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
Both CaaX-1(dis) and sC18-Cys(dis) internalized significantly stronger into cells compared with their reduced analogs
In vitro