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Peptide record

TPDB62161

sC18*-Tylotoin Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62161
sC18*-Tylotoin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
GLRKRLRKFRNKKCVRQNNKRVCK-NH2
Physicochemical Analysis
C128H234N52O29S2
ADEHIMPSTWY
RK
3029.72
12.42
12
0
5
+12
10.06
-1.708
56.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.13
6
Residue Composition
number
0
A
6
R
3
N
0
D
2
C
0
E
1
Q
1
G
0
H
0
I
2
L
6
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 3 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C128H234N52O29S2
3029.72
12.42
+12
10.06
-1.708
Amidation
L
Linear
Conjugated with CF
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HaCaT And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
CF dye
Cytosol and Nucleoli
Greater uptake compared to control peptides
In vitro
CHHHHHTTTSSTTGGGTCCTTCCC
Additional Detail Fields 1 fields
CHHHHHTTTSSTTGGGTCCTTCCC