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Peptide record

TPDB62160

sC18-Tylotoin Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB62160
sC18-Tylotoin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
GLRKRLRKFRNKIKEKKCVRQNNKRVCK-NH2
Physicochemical Analysis
C151H276N58O35S2
ADHMPSTWY
K
3528.34
12.16
14
1
6
+13
13.75
-1.707
62.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.54
6
Residue Composition
number
0
A
6
R
3
N
0
D
2
C
1
E
1
Q
1
G
0
H
1
I
2
L
8
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 3 D: 0 C: 2 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 2 K: 8 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
28
C151H276N58O35S2
3528.34
12.16
+13
13.75
-1.707
Amidation
L
Linear
Conjugated with CF
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HaCaT And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
CF dye
Cytosol and Nucleoli
Greater uptake compared to control peptides
In vitro
CHHHHHHHHGGGGGGGGTTTTEETTEEC
Additional Detail Fields 1 fields
CHHHHHHHHGGGGGGGGTTTTEETTEEC