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Peptide record

TPDB62155

HK15 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62155
HK15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: silica nanoparticles (NPs) N-terminal: Conjugated with CF
Sequence
GLRKRLRKFRNKIKAK-NH2
Physicochemical Analysis
C90H166N34O18
DCEQHMPSTWYV
K
2012.53
12.89
9
0
5
+9
5.89
-1.544
79.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C90H166N34O18
2012.53
12.89
+9
5.89
-1.544
Amidation
silica nanoparticles (NPs)
L
Amphipathic
Linear
Conjugated with CF
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
CF dye
Cytosol
3.7-fold higher internalization compared to the native sC18. Highest intracellular intensity levels were visible in the case of HK15 followed by HK17 and HK3.
In vitro
CHHHHHHHHHGGGGCC
Additional Detail Fields 1 fields
CHHHHHHHHHGGGGCC