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Peptide record

TPDB62128

EA Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB62128
EA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
GLKKLAELAHKLLKLGC-NH2
Physicochemical Analysis
C84H151N23O20S1
RNDQIMFPSTWYV
L
1835.32
10.17
5
1
8
+3
3.02
0.341
149.41
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
1
C
1
E
0
Q
2
G
1
H
0
I
6
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C84H151N23O20S1
1835.32
10.17
+3
3.02
0.341
Amidation
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, A549, PC12 and 3T3-L1 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Lower than RA
Endocytic pathway
In vitro
CHHHHHHHCSHHHHCC
Additional Detail Fields 1 fields
CHHHHHHHCSHHHHCC