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Peptide record

TPDB62126

Phage clone 1.2 Phage clone 1.3 T1 Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62126
Phage clone 1.2 Phage clone 1.3 T1
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLHTSATNLYLH
Physicochemical Analysis
C59H91N17O18
RDCEQIKMFPWV
L
1326.47
7.92
2
0
5
+0
-0.03
-0.050
105.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
112.33
5
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
2
H
0
I
3
L
0
K
0
M
0
F
0
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C59H91N17O18
1326.47
7.92
+0
-0.03
-0.050
Free
L
Linear
Linear
Free
Similarity
Cationic
GlyLeuHisThrSerAlaThrAsnLeuTyrLeuHis
NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
3.3 x 10e-7 cm/s

Target

SH-SY5Y cells

Assay & Model

UHPLC-MS/MS
The phage display adverses the BBB with the peptide.
Origin/Source
Stability/half life

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Peptides bound specifically to primary endothelial cells and could traverse the BBB.
Transcytosis
Combined with phage display
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Primary Rat Endothelial Cells And SH-SY5Y Neuroblastoma Cell Line.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
Biotin-labeled
Able to internalize into primary endothelial cells while internalization of N–C reversed sequence peptide into primary endothelial cells was negligible
Energy dependent pathway
In vitro
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Hepatocarcinoma-1, Lung adenocarcinoma, B16 Melanoma, Krebs-2 carcinoma, Lewis Lung carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Selection of antitumor displayed peptides for the specific delivery of the anticancer drug lactaptin
2016
Anna Andreevna Nemudraya et al. Oncol Lett. 2016 Dec 12(6):4547-4555.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
The hepatocarcinoma-1(HA-1), hepatocarcinoma-29(HA-29), lung adenocarcinoma (LA), Krebs-2 carcinoma, Lewis lung carcinoma, Ehrlich carcinoma strains, The В16 melanoma, human breast adenocarcinoma MDA-MB-231, MCF-7 cell line
3-4-month-old A/Sn, C57Bl/6, CBA, C3H strain mice (22-25 g)
Phage display library
RL2 (recombinant lactaptin analog), Cy5 (fluorescent dye)
Additional Detail Fields 3 fields
RL2 (recombinant lactaptin analog), Cy5 (fluorescent dye)
The hepatocarcinoma-1(HA-1), hepatocarcinoma-29(HA-29), lung adenocarcinoma (LA), Krebs-2 carcinoma, Lewis lung carcinoma, Ehrlich carcinoma strains, The В16 melanoma, human breast adenocarcinoma MDA-MB-231, MCF-7 cell line
3-4-month-old A/Sn, C57Bl/6, CBA, C3H strain mice (22-25 g)