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Peptide record

TPDB62121

2 × ppTG1 Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB62121
2 × ppTG1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with TAMRA Chemical: Lys side chain amine at the C-terminus
Sequence
GLFKALLKLLKSLWKLLLKAGLFKALLKLLKSLWKLLLKA
Physicochemical Analysis
C230H394N52O43
RNDCEQHIMPTYV
L
4575.98
11.46
10
0
26
+10
-6.54
0.950
185.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
240.39
2
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
18
L
10
K
0
M
2
F
0
P
2
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 18 K: 10 M: 0 F: 2 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
40
C230H394N52O43
4575.98
11.46
+10
-6.54
0.950
Conjugated with TAMRA
Lys side chain amine at the C-terminus
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

By-2 Cells Leaves Of Nicotiana Benthamiana, Arabidopsis Thaliana, Tomato (Solanum Lycopersicum), Poplar (Hybrid Aspen Populus Tremula×Tremuloides Line T89), And Rice (Oryza Sativa).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
TAMRA dye
2 × ppTG1 were the least efficient CPPs in BY-2 cells
In vitro
CTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC
Additional Detail Fields 1 fields
CTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC