Back to search

Peptide record

TPDB62115

DEN-K(HA2)-TAT (Pep 8) Cell-penetrating Peptides standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62115
DEN-K(HA2)-TAT (Pep 8)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 33-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Poly-L-lysine dendrons (DEN)
Sequence
GLFGAIAGFIENGWEGMIDGGRKKRRQRRRPPQ-NH2
Physicochemical Analysis
C164H265N57O43S1
CHSTYV
G
3755.32
12.12
8
3
10
+5
8.49
-1.039
53.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
146.46
3
Residue Composition
number
2
A
6
R
1
N
1
D
0
C
2
E
2
Q
7
G
0
H
3
I
1
L
2
K
1
M
2
F
2
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 1 C: 0 E: 2 Q: 2 G: 7 H: 0 I: 3 L: 1 K: 2 M: 1 F: 2 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
33
C164H265N57O43S1
3755.32
12.12
+5
8.49
-1.039
Amidation
Poly-L-lysine dendrons (DEN)
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
YOYO-1 labelled pEGFP plasmid
Cytoplasm and nucleus
Improved cellular uptake of pep 8 was ∼65% at N/P 5
In vitro
CCCTTGGGTSSCSSCCCSHHHHHHSSCC
Additional Detail Fields 1 fields
CCCTTGGGTSSCSSCCCSHHHHHHSSCC