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Peptide record

TPDB62103

Peptide2 Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62103
Peptide2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X = 1-aminoisobutylic acid (Aib) N-terminal: Conjugated with CF
Sequence
GKXTWWXTWWTXWSQPKKKRKV-NH2
Physicochemical Analysis
C123H177N33O25
ANDCEHILMFY
KW
2517.96
11.85
6
0
6
+6
-1.83
-1.486
13.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
27500
1092.15
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
22
C123H177N33O25
2517.96
11.85
+6
-1.83
-1.486
Amidation
X = 1-aminoisobutylic acid (Aib)
Modified
Amphiphilic
Linear
Conjugated with CF
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Amphiphilic
Chimeric
(5(6)-CF) dye
Cytoplasm and Endosomes/Lysosomes
Exhibited much greater membrane permeability than peptide 1
Endocytosis
In vitro