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Peptide record

TPDB62088

Peptide4 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62088
Peptide4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
GKATWWATWWTAWSQPKKKRKV-NH2
Physicochemical Analysis
C132H192N36O28
NDCEHILMFY
KW
2731.20
11.85
6
0
9
+6
-2.34
-1.241
26.82
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
27500
1006.88
5
Residue Composition
number
3
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
22
C132H192N36O28
2731.20
11.85
+6
-2.34
-1.241
Amidation
L
Amphiphilic
Linear
Conjugated with CF
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Chimeric
(5(6)-CF) dye
Cytoplasm and Endosomes/Lysosomes
Exhibited much greater membrane permeability than peptide 1
Endocytosis
In vitro
CCCGGGGTCCSCCCSCTTBTTTBC
Additional Detail Fields 1 fields
CCCGGGGTCCSCCCSCTTBTTTBC