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Peptide record

TPDB62053

B6 Blood-Brain Barrier Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB62053
B6
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 9-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Sequence
GHKAKGPRK
Physicochemical Analysis
C42H75N17O10
NDCEQILMFSTWYV
K
978.17
11.73
5
0
1
+4
5.04
-2.222
11.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
0
I
0
L
3
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C42H75N17O10
978.17
11.73
+4
5.04
-2.222
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HET-CAM (hen’s egg–CHOrioallantoic membrane)

Assay & Model

Adult male albino New Zealand rabbits ( 2.5 kg)
Adult male albino New Zealand rabbits ( 2.5 kg)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
PLGA nanoparticles loaded Licochalcone-A
B6 targeted nanoparticles provided greater therapeutic efficacy than Tet-1
In vitro and in vivo
CCSCGGGTTCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 and RAW 264.7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Licochalcone-A (Lico-A) PLGA NPs
In vitro
CCCSCTTSSSSCCCCCC
Additional Detail Fields 1 fields
CCSCGGGTTCCC CCCSCTTSSSSCCCCCC