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Peptide record

TPDB62047

MCoTI-M3 Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB62047
MCoTI-M3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
N-terminal: Conjugation with Alexa Flour 488
Sequence
GGVCPKILRRCRRDSDCPGACICRGNGWCGSGSD
Physicochemical Analysis
C140H232N52O45S6
EQHMFTY
G
3556.06
8.32
6
3
6
+3
5.94
-0.468
45.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
165.21
10
Residue Composition
number
1
A
5
R
1
N
3
D
6
C
0
E
0
Q
7
G
0
H
2
I
1
L
1
K
0
M
0
F
2
P
3
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 3 C: 6 E: 0 Q: 0 G: 7 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 2 S: 3 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
34
C140H232N52O45S6
3556.06
8.32
+3
5.94
-0.468
Free
L
Cationic
Cyclic
Conjugation with Alexa Flour 488
NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Fluorophore (Alexa Fluor 488)
Low (compared to native MCoTI-II)
Macropinocytosis, endocytosis
In vitro
CCCCHHHHTTSCCCCCCGGGSCCBTTBSSSSSCC
Additional Detail Fields 1 fields
CCCCHHHHTTSCCCCCCGGGSCCBTTBSSSSSCC