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Peptide record

TPDB62042

MCoK6A mutant Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB62042
MCoK6A mutant
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Cyclization N-terminal: Conjugation with Alexa-488
Sequence
GGVCPAILKKCRRDSDCPGACICRGNGYCGSGSD
Physicochemical Analysis
C135H224N46O46S6
EQHMFTW
G
3419.90
8.02
5
3
7
+2
6.05
-0.276
48.82
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
54.53
11
Residue Composition
number
2
A
3
R
1
N
3
D
6
C
0
E
0
Q
7
G
0
H
2
I
1
L
2
K
0
M
0
F
2
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 3 C: 6 E: 0 Q: 0 G: 7 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
34
C135H224N46O46S6
3419.90
8.02
+2
6.05
-0.276
Cyclization
L
Cyclic
Conjugation with Alexa-488
NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7 and MCF-7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Protein derived
Fluorophore (Alexa-488)
Endosomal compartments (vesicles)
Endocytic pathway
In vitro
CCSSHHHHHHHCCCSCCCSCCCCSSSSSCCSSCC
Additional Detail Fields 1 fields
CCSSHHHHHHHCCCSCCCSCCCCSSSSSCCSSCC