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Peptide record

TPDB62040

Pip6a Cell-penetrating Peptides modified_plain modified
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62040
Pip6a
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 24-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: B =β-alanine, GG linker
Sequence
GGRXRRBRRXRYQFLIRXRBRXRB-NH2
Physicochemical Analysis
C99H176N48O20
ANDCEHKMPSTWV
R
2358.80
13.00
10
0
4
+10
5.76
-1.646
32.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
63.17
2
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
24
C99H176N48O20
2358.80
13.00
+10
5.76
-1.646
Amidation
B =β-alanine, GG linker
Modified
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PBMCs, U937 Macrophages

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
FAM-labelled anti-miR-155 PNA
The percentage of labelled cells for the Pip6a conjugates was only 8% at 200nM
In vitro