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Peptide record

TPDB62038

CPP Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB62038
CPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: PEGylated
Sequence
GGRRRRRRRRR-NH2
Physicochemical Analysis
C58H116N38O12
ANDCEQHILKMFPSTWYV
R
1537.81
13.30
9
0
0
+9
7.31
-3.755
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C58H116N38O12
1537.81
13.30
+9
7.31
-3.755
Amidation
PEGylated
L
Linear
Free
NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Human Breast Cancer Cell Line

Assay & Model

Male Sprague Dawley rats (200±20 g) and BALB/c nude mice (20±2 g)
Male Sprague Dawley rats (200±20 g) and BALB/c nude mice (20±2 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Doxorubicin (DOX)
Cytosol
In vitro and in vivo
CCCSCCCCCCC
Additional Detail Fields 1 fields
CCCSCCCCCCC