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Peptide record

TPDB62037

R8 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB62037
R8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: GG linker
Sequence
GGRRRRRRRR-NH2
Physicochemical Analysis
C52H104N34O11
ANDCEQHILKMFPSTWYV
R
1381.62
13.25
8
0
0
+8
6.50
-3.680
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C52H104N34O11
1381.62
13.25
+8
6.50
-3.680
Amidation
GG linker
L
Linear
Free
NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PBMCs, U937 Macrophages

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM-labelled anti-miR-155 PNA
Cytoplasm and nucleus
At 200 nM, nearly all cells (> 98%) were positive for the FAM-PNA-R8 (at 20 nM > 60% )
In vitro
CTTSCCCCCC
Additional Detail Fields 1 fields
CTTSCCCCCC