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Peptide record

TPDB62027

E5TAT Cell-penetrating Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB62027
E5TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 37-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GGLFEAIAEFIENGWEGLIEGMGRKKRRQRRRPPQAS
Physicochemical Analysis
C185H299N61O52S1
DCHTYV
RG
4241.85
11.20
8
5
12
+3
12.71
-0.976
60.81
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
129.66
4
Residue Composition
number
3
A
6
R
1
N
0
D
0
C
5
E
2
Q
6
G
0
H
3
I
2
L
2
K
1
M
2
F
2
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 6 N: 1 D: 0 C: 0 E: 5 Q: 2 G: 6 H: 0 I: 3 L: 2 K: 2 M: 1 F: 2 P: 2 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
37
C185H299N61O52S1
4241.85
11.20
+3
12.71
-0.976
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
GFP-HiBiT fusion protein
Cytosol
Significantly enhanced delivery (7- to 30-fold increase)
Endocytosis
In vitro
CCCCGGGSCCTTTCC
Additional Detail Fields 1 fields
CCCCGGGSCCTTTCC