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Peptide record

TPDB62025

PNT-R5 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB62025
PNT-R5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acylation
Sequence
GGKKWKMRRN-NH2
Physicochemical Analysis
C54H93N21O12S1
ADCEQHILFPSTYV
K
1260.53
12.43
5
0
2
+5
2.95
-2.400
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
436.33
1
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
3
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 3 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
10
C54H93N21O12S1
1260.53
12.43
+5
2.95
-2.400
Amidation
L
Cationic
Linear
Acylation
NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Transparent Porcine Corneas(Isolated From Fresh Pig Eyes)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FAM-labelled at C terminus
Apparent permeability coefficients = 0.05 ± 0.01 × 10−6 (cm/s)(Donor concentration-250microMolar)
Ex vivo
CCCCSSSCCC
Additional Detail Fields 1 fields
CCCCSSSCCC