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Peptide record

TPDB62017

Penetratin Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62017
Penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: PMO Ivs2-654 Attached
Sequence
GGKGGRQIKIWFQNRRMKWKK
Physicochemical Analysis
C118H192N40O25S1
ADCEHLPSTYV
K
2603.14
12.72
8
0
6
+8
3.32
-1.581
37.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
422.57
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
4
G
0
H
2
I
0
L
5
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 4 H: 0 I: 2 L: 0 K: 5 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
21
C118H192N40O25S1
2603.14
12.72
+8
3.32
-1.581
Free
L
Amphipathic
Linear
PMO Ivs2-654 Attached
NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa 654

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
PMO IVS2-654-Biotin
Cytoplasm
L and D-peptides shared nearly identical PMO delivery activities
Endocytosis
In vitro
CHHHHHHHHTCC
Additional Detail Fields 1 fields
CHHHHHHHHTCC