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Peptide record

TPDB62013

MPG Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB62013
MPG
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: PMO Ivs2-654 Attached
Sequence
GGKGGLAFLGFLGAAGSTMGAWSQPKKKRKV
Physicochemical Analysis
C141H229N41O36S1
NDCEHIY
G
3106.68
11.85
6
0
12
+6
0.64
-0.168
60.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
177.04
4
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
1
Q
8
G
0
H
0
I
3
L
5
K
1
M
2
F
1
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 8 H: 0 I: 0 L: 3 K: 5 M: 1 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
31
C141H229N41O36S1
3106.68
11.85
+6
0.64
-0.168
Free
L
Amphipathic
Linear
PMO Ivs2-654 Attached
NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa 654

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Fusogenic
PMO IVS2-654-Biotin
Cytoplasm
L and D-peptides shared nearly identical PMO delivery activities
Endocytosis
In vitro
CCSCCSSSSCCCC
Additional Detail Fields 1 fields
CCSCCSSSSCCCC