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Peptide record

TPDB62006

TAT Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62006
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GGGYGRKKRRQRRR
Physicochemical Analysis
C70H127N35O17
ANDCEHILMFPSTWV
R
1731.00
12.71
8
0
1
+8
6.52
-2.943
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
86.08
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
4
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C70H127N35O17
1731.00
12.71
+8
6.52
-2.943
Free
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 And A549T Cells.

Assay & Model

Four-week-old female BALB/c nude mice
Four-week-old female BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Paclitaxel (PTX)-Succinic acid (SA)
In both A549 and A549T cells treated with PTX-CPPs had higher cellular uptake of PTX than cells incubated with PTX alone.
Energy-independent direct translocation
In vitro and in vivo
CCCCCSSSCCCCCCSSSCC
Additional Detail Fields 1 fields
CCCCCSSSCCCCCCSSSCC