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Peptide record

TPDB62001

RWFW9 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB62001
RWFW9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: G4 linker N-terminal: Biotinylation
Sequence
GGGGRRWFRRWRR-NH2
Physicochemical Analysis
C75H115N33O14
ANDCEQHILKMPSTYV
R
1702.95
13.10
6
0
3
+6
0.07
-2.123
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
645.94
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C75H115N33O14
1702.95
13.10
+6
0.07
-2.123
Amidation
G4 linker
L
Linear
Biotinylation
NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Much less internalized (~ 1 pmol or less) than RW9 (~ 10 pmol) shows about a ten-fold decrease
In vitro
CCCCCGGGGGTCC
Additional Detail Fields 1 fields
CCCCCGGGGGTCC