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Peptide record

TPDB61991

Biotin-Penetratin Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61991
Biotin-Penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation
Sequence
GGGGRQIKIWFQNRRMKWKK-NH2
Physicochemical Analysis
C112H180N38O24S1
ADCEHLPSTYV
GK
2474.96
12.72
7
0
6
+7
2.33
-1.465
39.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
444.45
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
4
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 4 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
20
C112H180N38O24S1
2474.96
12.72
+7
2.33
-1.465
Amidation
L
Cationic
Linear
Biotinylation
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 cells (WT), CHO-pgsA745 cells (GAGdeficient) and CHO-lec2 cells (SAdeficient)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Cytosol
N-terminal biotin-(Gly4) tag is detrimental to the internalization efficiency of the CPP.
Direct translocation and endocytosis
In vitro
CTTTSCCCCHHHHHTGGGGTC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC