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Peptide record

TPDB61985

pHLIP-KLAKLAK Cell-penetrating Peptides standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB61985
pHLIP-KLAKLAK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 45-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCGKLAKLAK
Physicochemical Analysis
C230H357N55O65S1
HMS
L
4964.75
4.31
4
6
23
-2
1.29
0.162
115.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
13980
281.58
8
Residue Composition
number
6
A
1
R
1
N
4
D
1
C
2
E
1
Q
4
G
0
H
1
I
10
L
3
K
0
M
1
F
2
P
0
S
3
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 6 R: 1 N: 1 D: 4 C: 1 E: 2 Q: 1 G: 4 H: 0 I: 1 L: 10 K: 3 M: 0 F: 1 P: 2 S: 0 T: 3 W: 2 Y: 2 V: 1
Chemical Descriptors
45
C230H357N55O65S1
4964.75
4.31
-2
1.29
0.162
Free
L
Cationic
Linear
Free
NCC(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
KLAKLAK peptide
In vitro
CCCSSTTCCCSSSCSSCCSTTTTTCSSSCCCSCCSSSCCTTC
Additional Detail Fields 1 fields
CCCSSTTCCCSSSCSSCCSTTTTTCSSSCCCSCCSSSCCTTC