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Peptide record

TPDB61978

III-67B Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61978
III-67B
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: O = Ornithine N-terminal: Acetylation
Sequence
Ac-GGAYAAPFKKKA-NH2
Physicochemical Analysis
C57H89N15O14
RNDCEQHILMSTWV
A
1208.43
10.46
3
0
6
+3
0.69
-0.450
33.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
123.30
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
3
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 3 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C57H89N15O14
1208.43
10.46
+3
0.69
-0.450
Amidation
O = Ornithine
L
β-hairpin
Acetylation
NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues β-hairpin L
Synthetic
FAM-labelled
Not capable of cellular entry
In vitro
CCSCCSCCSSCC
Additional Detail Fields 1 fields
CCSCCSCCSSCC