Back to search

Peptide record

TPDB61975

GF19 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61975
GF19
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
GFKRIVQRIKDFLRNLVKL-NH2
Physicochemical Analysis
C109H187N33O24
ACEHMPSTWY
RLK
2343.89
12.14
6
1
9
+5
3.22
-0.089
133.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
1
Q
1
G
0
H
2
I
3
L
3
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 3 K: 3 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
19
C109H187N33O24
2343.89
12.14
+5
3.22
-0.089
Amidation
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcec Cells And Eye Corneas

Assay & Model

C57BL/6 J mice (6 to 12 weeks old males)
C57BL/6 J mice (6 to 12 weeks old males)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Silica Nanoparticles
Addition of -KL to the -C terminal of GF-17 theoretically enhances the membrane rupturing ability of GF19.
In-vitro, in-vivo and ex vivo
CTTCCTTCCC
Additional Detail Fields 1 fields
CTTCCTTCCC