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Peptide record

TPDB61974

H2 (H18R) Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB61974
H2 (H18R)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GFGCNGPWNEDDLRCRNHCKSIKGYKGGYCAKGGFVCKCY
Physicochemical Analysis
C191H285N57O54S6
QMT
G
4436.07
8.56
8
3
10
+4
4.59
-0.705
29.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
10345
233.20
13
Residue Composition
number
1
A
2
R
3
N
2
D
6
C
1
E
0
Q
8
G
1
H
1
I
1
L
5
K
0
M
2
F
1
P
1
S
0
T
1
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 3 D: 2 C: 6 E: 1 Q: 0 G: 8 H: 1 I: 1 L: 1 K: 5 M: 0 F: 2 P: 1 S: 1 T: 0 W: 1 Y: 3 V: 1
Chemical Descriptors
40
C191H285N57O54S6
4436.07
8.56
+4
4.59
-0.705
Free
L
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mac-T Cells (Infected With Mrsa And S. Aureus Cvcc3051)

Assay & Model

ICR mouse mastitis model
ICR mouse mastitis model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-conjugated
Cytoplasm
After treatment with 0.25, 2.5, and 25 μg/ml FITC-H2, the percentages of cells showing fluorescence were 90.6%, 100%, and 100%, respectively, which is almost identical to those in the case of NZ2114 (90.5–99.9%).
Clathrin mediated endocytosis
In vitro and in vivo
CHHHHHHHHHHHHSGGGSCSCCCCC
Additional Detail Fields 1 fields
CHHHHHHHHHHHHSGGGSCSCCCCC