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Peptide record

TPDB61960

MCaUF1–9(Ala)-C-GNP Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61960
MCaUF1–9(Ala)-C-GNP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
GDALPHLKLC
Physicochemical Analysis
C47H79N13O13S1
RNEQIMFSTWYV
L
1066.28
7.15
2
1
4
+0
1.55
0.310
127.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
1
D
1
C
0
E
0
Q
1
G
1
H
0
I
3
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 3 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C47H79N13O13S1
1066.28
7.15
+0
1.55
0.310
Addition of Cysteine
L
Linear
Free
NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, MDA-MB-231 And A432 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Gold Nanoparticles
24.2% MCaUF1–9(Ala)-C-GNP were internalized in MDA-MB-231 and 9.9 % in A431 were uptake after 2h incubation. No specificity towards HeLa cells
In vitro
CCSSCSSCC
Additional Detail Fields 1 fields
CCSSCSSCC