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Peptide record

TPDB61957

BP16 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB61957
BP16
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Dimethylacetamide Anhydride (DMA) N-terminal: Acetylation And 5(6)-Carboxyfluorescein
Sequence
GCKKLFKKILKKL
Physicochemical Analysis
C74H135N19O14S1
ARNDEQHMPSTWYV
K
1547.06
10.82
6
0
5
+6
2.59
-0.200
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
3
L
6
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 6 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C74H135N19O14S1
1547.06
10.82
+6
2.59
-0.200
Free
Dimethylacetamide Anhydride (DMA)
L
Linear
Acetylation And 5(6)-Carboxyfluorescein
N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht29 Cell , Ht29 3D Spheroids

Assay & Model

Nude mice
Nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Cytochrome C
Cytoplasm and nucleus
DMA.CPP-CytC demonstrated pH-dependent penetration into cells.
In-vitro, in-vivo and ex vivo
CCCSSCCCCCC
Additional Detail Fields 1 fields
CCCSSCCCCCC