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Peptide record

TPDB61956

cPF4Pext_pDI_A488 Cell-penetrating Peptides modified_plain modified
43 amino acids
Basic Information
3D PDB MODEL
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TPDB61956
cPF4Pext_pDI_A488
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 43-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X = azidoalanine
Sequence
GCGGPLYKKIIKKLLESIIKKGGXGGSGGLTFEHYWAQLTGGC-NH2
Physicochemical Analysis
C199H318N52O54S2
RNDMV
G
4367.15
9.75
7
2
14
+4
3.07
-0.070
83.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8605
197.04
9
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
2
E
1
Q
11
G
1
H
4
I
5
L
6
K
0
M
1
F
1
P
2
S
2
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 2 Q: 1 G: 11 H: 1 I: 4 L: 5 K: 6 M: 0 F: 1 P: 1 S: 2 T: 2 W: 1 Y: 2 V: 0
Chemical Descriptors
43
C199H318N52O54S2
4367.15
9.75
+4
3.07
-0.070
Amidation
X = azidoalanine
Modified
Cationic
Cyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mm96L And Hacat Cells MCF7 And MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Cyclic Modified Cationic
Synthetic
A488 dye
Cytoplasm
Trend in internalization efficacy was similar for cPF4PD-A488 and cPF4Pext_pDI-A488 with MM96L ~ MDA-MB-231 > HaCaT > MCF7.
In vitro