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Peptide record

TPDB61954

DPV15b Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB61954
DPV15b
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Cys addition
Sequence
GAYDLRRRERQSRLRRRERQSR
Physicochemical Analysis
C116H206N54O34
NCHIKMFPTWV
R
2901.25
12.40
10
3
4
+7
12.57
-2.564
40.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
51.36
5
Residue Composition
number
1
A
10
R
0
N
1
D
0
C
2
E
2
Q
1
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 10 N: 0 D: 1 C: 0 E: 2 Q: 2 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C116H206N54O34
2901.25
12.40
+7
12.57
-2.564
Free
L
Linear
Cys addition
NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, HCT116, HL-60, K562, Molt4, NIH-3T3 and primary hepatocyte cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Protein (PO and IgG)
Nucleus
Energy-dependent endocytic process involving cell membrane lipid rafts
In vitro
CCSCCSTTTHHHHTGGGTCCCC
Additional Detail Fields 1 fields
CCSCCSTTTHHHHTGGGTCCCC