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Peptide record

TPDB61949

MPGΔNLS Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB61949
MPGΔNLS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
GALFLGFLGAAGSTMGAWSQPKSKRKVC
Physicochemical Analysis
C129H206N36O34S2
NDEHIY
G
2869.40
10.83
4
0
12
+4
-1.48
0.196
66.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
191.68
6
Residue Composition
number
4
A
1
R
0
N
0
D
1
C
0
E
1
Q
5
G
0
H
0
I
3
L
3
K
1
M
2
F
1
P
3
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 3 K: 3 M: 1 F: 2 P: 1 S: 3 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
28
C129H206N36O34S2
2869.40
10.83
+4
-1.48
0.196
Addition of Cysteine
L
Amphipathic
Linear
Free
NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors
Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Chimeric
Indocyanine green (ICG)-labeled Lactosomes (A3B-type)
In vitro and in vivo
CTTTCTTSEETTEETTTTTSCCCSSCCC
Additional Detail Fields 1 fields
CTTTCTTSEETTEETTTTTSCCCSSCCC